The effect of nutritional supplementation in pregnancy on the bone health, body composition and nutrient intake of mother and child: ENID-Bone

ING Staff: Landing Jarjou, Yankuba Sawo, Gail Goldberg, Kate Ward, Inez Schoenmakers, Ann Prentice

This study complements and expands our previous work on calcium and bone metabolism in pregnancy and lactation.

Sample collections for measurement of calcium and bone metabolism, and bone imaging (pQCT and/or DXA) are made at booking, 20wk and 30wk gestation, and 2 and 13 wk postpartum (mothers and babies), at the same visits as for the main study. In addition we are collecting 24-hour urine samples and doing 2-day dietary assessments at the woman’s home. We are also measuring non-pregnant and non-lactating (NPNL) women who are enrolled in ENID, so we have longitudinal data from a NPNL baseline.

Primary aims:

  • To determine whether maternal nutrition during pregnancy affects the growth and development of the fetal skeleton and subsequent bone accretion of the infant.
  • To investigate whether the nutritional environment during pregnancy modulates the maternal skeletal response to pregnancy and lactation with potential consequences for current and later bone health of the woman.
  • To determine the effects of pregnancy supplementation on the lean and fat masses of the mother and infant in order to consider their influences on the skeleton and to contribute specialist data on body composition to the main trial.

Secondary aims:

  • To explore underlying mechanisms and to consider whether the nutritional status of the mother pre-pregnancy influences the pattern of maternal changes of bone and body composition in pregnancy and lactation, and the growth of the child.

 

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